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Endoplasmic reticulum (ER) stress occurs when cells experience environmental pressures such as hypoxia, inflammation, and oxidative stress, leading to ER dysfunction, abnormal protein folding, and the activation of various signaling pathways that affect cellular homeostasis (168)
A separate ziplock bag held the injection supplies, medication information, and instructions, with extra sharps and alcohol wipes and no branded materials
Although NO is certainly antiproliferative towards T lymphocytes, subsequent studies have failed to confirm a selective effect of NO on Th1 versus Th2 cells [13,78,79], casting doubt on the hypothesis of NO-driven asthma [20]
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