The administration of liraglutide significantly attenuated PCOS-associated ovarian MGCs apoptosis in a concentration-dependent manner, and these effects were associated to modifications of the phosphorylation sites of forkhead box protein O1 (FoxO1), a negative regulator of cell survival
To ensure that this was not an effect of the modified (pGlu-Gln)-CCK-8 peptide, we repeated the assay with sulfated CCK-8, a native CCK peptide 27 , and still did not stimulate insulin secretion in -cells whether normalized to insulin content or DNA content (Suppl
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International journal of cell biology
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