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The nod came nearly eight years after Lonsurf first won approval as a monotherapy for mCRC in Sept

retatrutide research uk 2 GLP-1 Receptor (GLP-1R) GLP-1 receptor activation is responsible for: Enhanced insulin secretion Slowed gastric emptying Increased satiety signalling Reduced caloric intake Compared to dedicated GLP-1 agonists like semaglutide, retatrutide demonstrates balanced but slightly milder GLP-1 activation

doi: 10.1006/excr.1999.4667

Mean bodyweight was reduced by 4.6 kg (SE 0.28) with semaglutide 0.5 mg compared with 2.3 kg (0.27) with dulaglutide 0.75 mg (estimated treatment difference 2.26 kg [3.02 to 1.51]

A small percentage of users experience ongoing constipation or acid reflux throughout treatment