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Genetic Defects and Their Impact Mutations in the genes encoding carnitine biosynthesis enzymes can result in primary carnitine deficiency

Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis

Model analysis Selection of parameters for estimation The methodology to select parameters for estimation involves first conducting local sensitivity analysis (LSA) to obtain a set of important parameters, and then determining from this set of parameters which are identifiable, that is for which parameters a value can be identified from the data, taking into account the model structure

"Intracellular free iron and its potential role in ultrahigh-pressure-induced inactivation of Escherichia coli"

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Even slight modulations in the cellular redox state can produce neurotoxic species