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Data availability The data that support the findings of this study are available within the paper and its Supplementary Information or from the corresponding authors upon request

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Under unstressed condition, NRF2 is constantly ubiquitinated by KEAP1-CUL3 ubiquitin E3 ligase, in which KEAP1 serves as a substrate recognition subunit

Their effectiveness in the long run requires their combination with the following: Healthy eating habits Regular physical activity Ongoing medical supervision The weight loss from GLP-1 drugs must be slow and sustainable rather than quick and erratic

It is recommended to start with a series of treatments, once a week for a month, and then move to a maintenance schedule based on your body's response and your doctor's advice

10.1074/jbc.M114.574335 268 SuX.WellenK