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GLP-1 RAs are preferred second-line agents in patients with T2DM with established atherosclerotic cardiovascular diseases (ASCVD) in light of their demonstrated ASCVD benefit, high efficacy, low potential for hypoglycaemia and potential for weight loss

That's not just clinically valuable

Patients taking levothyroxine (if they have developed hypothyroidism post-treatment for Graves' disease) should take it consistently, ideally on an empty stomach in the morning, and thyroid function should be monitored to ensure adequate replacement

These work today, are covered by insurance, and have decades of research backing them

10.1253/circj.CJ-16-0924 11

Rybelsus is a once-daily pill