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Furthermore, rescue experiments with antioxidant N-acetylcysteine (NAC) showed that the expression of 4-HNE and the apoptosis in SGNs were significantly decreased, while the number of surviving SGNs was increased in peroxynitrite + NAC group compared the peroxynitrite-only group and in peroxynitrite + gpx1 / + NAC group vs
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In high-fat diet-induced obese mice, the abundance of Blautia producta in the gut flora increases, leading to elevated 2-OG levels
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Applications: Chronic inflammation, oxidative stress conditions, and DNA damage-related disorders
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