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Interestingly, reactivation of AKT/mTOR signaling by using small molecule PI3K antagonists activates the transport of energy-active mitochondria to the cortical cytoskeleton of cancer cells, therefore heightening tumor cell invasion (202)

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After perfusion, brains were collected and post-fixed overnight at 4 C in paraformaldehyde

At times, frustration or even a loss of quality of life from the reduced pleasure obtained from food (or other aspects of life) may result in changes in affect and potentially medication discontinuation [148]

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