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Reactive oxygen species (ROS) or free radicals cause damage to key cellular components like DNA, RNA, lipids, proteins, and structural membranes

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Oncotarget 6:2200622027 Esworthy RS, Mann JR, Sam M, Chu FF (2000) Low glutathione peroxidase activity in Gpx1 knockout mice protects jejunum crypts from gamma-irradiation damage

Conversely, naringin has been shown to promote the differentiation and maturation of DCs through the KBP4/NR3C1/NRF2 axis, thus providing a novel therapeutic approach for NRF2-dependent autoinflammatory conditions (115)

Results vary based on individual factors including age, baseline hormone levels, diet, exercise habits, and treatment compliance