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2 Treatment groups Experimental Treatment Active Control Participants will receive 2.4 mg cagrilintide and 2.4 mg semaglutide subcutaneously once-weekly (dose escalation period of 16 weeks) for up to 84 weeks

The TRIUMPH Phase 3 program uses 9 mg and 12 mg as the primary therapeutic doses, with a 4 mg maintenance dose being explored for weight maintenance after initial loss

Limitations Adverse Effects Although GLP1-RA help improve glycemic control, promote weight loss, and reduce cardiovascular events, there are several limitations to its use

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Unlike NK cells, which can circulate, ILCs predominantly maintain tissue residency and establish specialized niches within organs such as the gut, skin, lung, liver, and adipose tissue (102, 103)