IGF-1 replacement therapy induced a restoration of the altered GH/IGF-1 axis by reducing circulating GH levels and recovering the somatostatinergic tone [292]
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Metabolism slows with age due to factors like reduced physical activity and muscle loss
Aside from protecting cells from damage due to excessive oxygen or nitrogen radicals, glutathione plays a number of other key roles, including (1) : Detoxification of toxic compounds Facilitating plasma membrane transport of toxic substances for elimination Scavenging oxygen and nitrogen oxidants Recycling and regenerating other antioxidants (vitamins C and E) Removing heavy metals Regulating cell proliferation and apoptosis Supporting mitochondrial function and maintaining the health of mitochondrial DNA Without sufficient glutathione production or intake, low glutathione status can contribute to the development or worsening of various disease states, some of which include (2, 3) : Premature aging Neurodegenerative disorders (Alzheimers, Parkinsons) Cancer Diabetes HIV/AIDS Autoimmunity Infertility Mental health disorders Its a little nutrient that plays a big role, so supporting it in any way you can is critical to maintaining health and preventing chronic disease development
IRS is a key factor in signal transduction of insulin and IGF-1 (Figure 2A)
Preclinical and observational data available for the individual components
