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Cold sores or genital herpes: Among over 12,000 supplement-related ED consultations logged by Allo Health, less than 4% of users reported mild side effects like bloating or headaches, most of which resolved by lowering the dose

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So theres definitely real-world evidence of a mortality benefit to these medications. And because the drugs can reduce the risk of serious health issues from untreated diabetes, they can improve lifespan in people with that condition, or prediabetes, as well

doi: 10.1016/j.heliyon.2023.e20284