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According to different reaction mechanisms, the representative bioorthogonal reactions that have been developed include Staudinger ligation, copper-catalyzed azide-alkyne cycloaddition, and inverse electron-demand Diels-Alder reactions

More recently, a study comparing subjects with central obesity only with subjects suffering from the metabolic syndrome showed changes in ghrelin levels not to be associated with central obesity per se but with other components of the metabolic syndrome (524)

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Another study demonstrated CQDs loaded with doxorubicin or combined with multifunctional platforms ( i.e