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lean mass retention is the number that matters

Some of the improvement appears tied to the amount of weight lost

Theyre less responsive to cues in our environment that are saying, 'Its time to have a large serving of ice cream or whatever

An exploratory mediation analysis of the effects on kidney outcomes (composite of macroalbuminuria, decreased GFR, renal death) with liraglutide and semaglutide in patients with T2DM in the LEADER and SUSTAIN-6 trials observed that HbA1c mediated 2526% and SBP 922% of kidney effects with a negligible contribution of the other parameters studied, such as body weight [15]

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