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The mitochondrial version of fumarate hydratase (a 510 amino acid protein) is extended at the N-terminus, relative to the cytosolic form of the enzyme

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January 26, 2022 blood tests: serum B12: 307 pmol/l serum methylmalonic acid: 112 nmol/l February 10, 2022 blood test: serum homocysteine: 10.3 mol/l These results, especially the reduction in methylmalonic acid to a low level, indicate that a daily multivitamin with 6 g of B12 was enough to maintain a healthy B12 status

However, further preclinical studies, especially those focusing on ALD and MetALD models, and prospective clinical trials are necessary to fully translate these promising anticancer benefits to human patients