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Berberine, a plant-derived alkaloid, works primarily by activating AMP-activated protein kinase (AMPK), influencing glucose and lipid metabolism

& Le, K.D.R

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Diet-derived ceramides species might target and disrupt mitochondria function leading to defective energy balance and neurodegeneration

J Neurosci 23(13):59285935

WCV treatment reduced these levels close to those of the control in the VM group, whereas PD-1 antibody treatment did not rescue these levels in the PM group (Fig