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Pharmacokinetics (ADME) Absorption Well absorbed orally Rapid onset Distribution Highly protein bound (~99%) Metabolism Mainly hepatic metabolism Glucuronidation is significant Half-life About 23 hours But effect lasts longer due to enzyme inhibition Excretion Mainly via bile/feces Some renal excretion --- 5

See the doctor ASAP if you have black or dark red bowel movements and/or a fever, sharp pain, trouble breathing, dizziness, or weight loss

Drinking plenty of water can help alleviate these symptoms by keeping your digestive system moving smoothly

It's a good time to catch up on reading or social media

For some women, GLP-1 medications relieve endo belly

Immuno-Oncology PA PD-1, PD-L1 inhibitors, and targeted oncology biologics