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doi: 10.1007/s40572-018-0187-y 189

The murine ortholog of URAT1, the renal-specific transporter protein RST, is predominantly situated on the apical surface of proximal tubules in the kidneys [55, 56, 85, 86, 87]

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For instance, MC4-NN2-0453, which did not demonstrate clinical efficacy, achieved substantial peripheral circulation but may have had limited central penetrance

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