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Interestingly, Chen and coworkers demonstrated, in chronic unpredictable mild stress protocol, the beneficial effects of chaingun granules, which lead to neuroprotection through the reduction of xanthines content and ROS, antidepressant effects observed in SPT, FST, OFT and EPM and anti-inflammatory response by inhibiting the xanthineP2X7R-NLRP3 inflammasome pathway and decreasing TNF-alpha, IL-1

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The above results indicated that the trends in change of estrogen, CYP3A4, ER and oxidative stress indicators in our cell model exposed to fullerenols were consistent with those detected in our in vivo model