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Figure 5 summarises the regulation of GLP-1 secretion

As discussed in our previous blog, these miracle drugs for treating obesity and type-2 diabetes are in high demand, with limited supply and only a few manufacturing companies competing for the market share

metformin, apart from an isolated case of improvement in ballooning degeneration, did not significantly resolve NASH [50]

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GLP-1R also functions as a pleiotropic GPCR that can activate distinct signaling cascades depending on ligand bias and the local cellular environment [511]