In Phase 2 trials published in the *New England Journal of Medicine* (2023), participants lost an average of 17.5% of body weight at the highest dose over 24 weeks outperforming tirzepatide and semaglutide in head-to-head data comparisons
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AOD9604, by contrast, is not FDAapproved as an obesity medication, and while safety data are reassuring, its use for weight loss remains offlabel with mixed evidence for effectiveness
To address the functional role of HSL in vivo, several laboratories generated HSL-null mouse models (44, 94, 134)
Its important because B deficiency can cause serious issues like pernicious anemia and nerve damage
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