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Metabolic and WeightRelated Research Triple receptor coactivation has been investigated for pronounced effects on satiety, reduced caloric intake, and bodyweight endpoints in controlled studies

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However, a 3-fold increase in plasma exposure to tacrolimus in a renal transplant patient (CYP3A5 non-expresser) upon initiation of amlodipine for the treatment of post-transplant hypertension resulting in reduction of tacrolimus dose has been reported

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