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In laboratory settings, the peptide has been studied in preclinical models that examine cellular signaling and experimental responses across multiple tissue systems

DSIP has further been shown to reduce corticotropin, and stimulate secretion of luteinizing hormone (LH)

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found human patients with congenital cerebellar ataxia with the same gain of function mutation in the GluR2 receptor as Lurcher mice, which also made them a human disease model [240]