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For example, a study published in the New England Journal of Medicine in 2021 found that patients on tirzepatide lost an average of 7.6 kg, 9.3 kg or 11.2 kg, depending on dosage, while those on semaglutide, all on the same dosage, lost an average of 5.7 kg over 40 weeks

The primary B12 risk is indirect: marked appetite suppression may reduce consumption of animal-derived foods, the main dietary source of B12

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"In vitamin B12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrations"

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