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They may experience chemical degradation, conformational changes, or formulation-related instability over time

A 10mg vial targeting 2.5mg/mL concentration requires 4mL bacteriostatic water (10mg 2.5mg/mL = 4mL), yielding 20 doses at 0.5mg per 0.2mL injection instead of 10

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NETs have been observed to be associated with various causes of AKI, including glomerulonephritis, ischemic AKI, septic AKI, and Systemic lupus erythematosus (SLE) (94, 98100)