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I personally have diagnosed three patients with scurvy, a disease that was diagnosed in British sailors in the 1800s, who had limited access to fresh fruit

J Neurosci Res 68:6575 Chen Y, Vartiainen NE, Ying W, Chan PH, Koistinaho J, Swanson RA (2001) Astrocytes protect neurons from nitric oxide toxicity by a glutathione-dependent mechanism

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This has been demonstrated in multiple studies with rats and swine, where growth hormone levels significantly increased after injections without impacting ACTH and cortisol plasma levels: In pentobarbital anaesthetised rats, ipamorelin released GH with a potency and efficacy comparable to GHRP-6 (ED50 = 80+/-42nmol/kg and Emax = 1545+/-250ng GH/ml vs 115+/-36nmol/kg and 1167+/-120ng GH/ml)

10.1016/j.redox.2015.09.005 32 DebloisG.St-PierreJ.GigureV