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Thats quite a Rube Goldberg-like set of contortions, he adds

Further electrophysiological study showed that, opposite to the effects on arcuate POMC neurons, GLP-1 hyperpolarizes arcuate NPY neurons indirectly via increased GABA A receptor-mediated neurotransmission of local GABAergic interneurons (Secher et al., 2014

Yao, Y., Xu, X