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Gene therapy involves intra-articular injection of vectors into the diseased joint to promote the apoptosis of target cells or continuously express their products against pathogenic factors ( Figure 5 )

In standard laboratory models, native IGF-1 has a very short half-life (approximately 20 minutes) because it is rapidly neutralized by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Senescent CAFs mediate immunosuppression and drive breast cancer progression

Correlation between genotype, metabolic data, and clinical presentation in carnitine palmitoyltransferase 2 (CPT2) deficiency

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