These tau aggregates can assemble, leading to the formation of oligomers, straight filaments, and paired helical filaments, which are neurotoxic
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Ultimately, through the interactive regulation of core targets such as mTOR-PHD2/HIF1-RhoA/p27, it achieves multiple effects including anti-inflammation, anti-fibrosis, and inhibition of vascular remodeling
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Arnon, T