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The dosage of L-T4 should be adapted based on the patients BMI, lean body mass, age, sex, and other factors affecting L-T4 absorption and metabolism [79,80,81,82]

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doi: 10.1046/j.1471-4159.2003.01812.x 138 PerryTGreigNH

Cell culture and generation of stable cell lines PathHunter CHO-GLP-1R -arrestin-1/-2 reporter cell lines (DiscoverX) were maintained in the manufacturers Culture Medium

Therefore, in this review our aim is to bring all IGF-1 information regarding metabolism together with the objective of offering clear insight into the issuethis way clarifying how miss-regulation of the GH/IGF-1/insulin axis can lead to metabolic disorders such as MetS and diabetes