However, most existing data on the effect of GLP-1R phosphorylation in regulating receptor signalling responses are indirect (4, 6, 7), and/or have been collected from heterologous expression systems (4, 5, 7, 8), so that the validity of these observations in physiologically relevant models with endogenous expression of the receptor and its downstream signalling mediators [GRKs, -arrestins, phosphodiesterases (PDEs), endosomal trafficking regulators, etc.] is currently unknown
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This data point is central for two reasons
however, histological changes and liver fibrosis stage were not assessed in this study [77]
In this context, the strict regulation of prescribing and reimbursement rules helps to limit misuse and reserve these medicines for medically justified situations
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