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1 Steady-state concentrations are reached after roughly five weeks of once-weekly dosing, with substantial carryover from one week to the next

Extreme weakness, fainting, or confusion are also red flags that need immediate attention

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3S refers to 3 cells in a series

Together, these findings demonstrate that, in contrast with acute exposure, chronic disruption of iron homeostasis with consequent GSH depletion remodels cellular redox homeostasis over time, inducing a state we term chronoferroptosis: a persistent ferroptotic adaptation characterized by coordinated alterations in iron-handling and antioxidant defense proteins that may represent early vulnerability to neurodegenerative pathology