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Phosphorylation of Drp1 at Ser637 by Ca 2+ /calmodulin-dependent protein kinase I (CaMKI) and protein kinase A (PKA) has an opposite, inhibitory effect on mitochondrial fission [316, 317]
In some embodiments, local otic delivery of the auris formulations or compositions described herein allows for controlled release of active agents to auris structures and overcomes the drawbacks associated with systemic administration (e.g., low bioavailability of the drug in the endolymph or perilymph, variability in concentration of the drug in the external, middle and/or internal ear)
The five IU of pregnant mares serum gonadotropin (PMSG
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Exogenous HGF treatment shows an anti-fibrotic activity in animal models, such as the tMCAO model, exerted through the decrease of glial scar formation and scar thickness of the brain pia matter (Shang et al., 2011)
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