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Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the Nanog, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell MicroRNAs

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Colletti A, Pellizzato M, Cicero AF

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this is specifically a concern in fibrosis, wherein ROS pathways are often upregulated 27

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