Nat Protoc 4 : 4457
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This compound not only inhibited SARM1s NADase activity effectively but also exhibited a favorable safety profile, making it a strong candidate for further development 233
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Instead, GLP-1 modulates calcium signaling pathways through protein kinase A (PKA)-dependent phosphorylation of calcium-cycling proteins, thereby altering action potential morphology and dominant pacemaker sites, ultimately leading to an increase in heart rate (147)
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