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doi: 10.1111/neup.2017.37.issue-5 73 XieLLiWHershJLiuRYangSH

Serious hypersensitivity reactions, including anaphylaxis and angioedema have been reported with dapagliflozin [see ADVERSE REACTIONS ]

Similarly, expression of cell signature genes, transthyretin ( TTR ), vitamin Dbinding protein ( GC ), crystallin A2 ( CRYBA2 ), aldehyde dehydrogenase 1 family member A1 ( ALDH1A1 ), and transmembrane 4 L 6 family member 4 ( TM4SF4 ), was highest in the -3 and 4 subclusters (Figure 3D)

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Classically, three metabolic alterations have been identified that contribute to the development of T2DM: 1) insulin resistance, 2) an eventual decrease in insulin secretion from pancreatic beta cells, and 3) an excess production of glucose from the liver