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However, as with other lipid-based nanosystems, key challenges remain, including ensuring long-term formulation stability, evaluating safety with repeated topical application, and scaling up production for clinical-grade batches [123, 124, 134]

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Results showed that GHK-Cu upregulated SIRT1 protein expression and suppressed the expression of phosphorylated p-STAT3 in colon tissue and MCECs of the co-culture model

A circadian gene expression atlas in mammals: implications for biology and medicine