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Molecular mechanism of ferroptosis in orthopedic diseases

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Whilst one study on L cell-like lines did not support a direct effect of metformin on L cells to mediate this effect [60], a more recent study has reported a direct effect of metformin on these cells, where an increase in the expression of the gene encoding proglucagon by metformin is mediated via a -cateninTCF7L2-mediated mechanism [63, 65]

Crucial for adaptive immunity (targeting a specific pathogen)

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Were getting larger, sicker and more difficult to treat, he said