Obesity induces metabolic disturbances in adipose tissue, influencing the release of hormones, adipokines, inflammatory cytokines, growth factors, enzymes, and free fatty acids [12]
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Lifestyle modifications that may help include wearing loose, soft-textured clothing made from natural fibers, using silk or satin bedsheets that produce less friction, maintaining a consistent room temperature to avoid thermal triggers, practicing stress reduction techniques since psychological stress can amplify central sensitization, and optimizing sleep hygiene since poor sleep worsens pain perception
This approach can lower the likelihood and seriousness of unwanted effects
Devon Gholam, VP science and innovation at ingredient incubator and innovation firm Step Change Innovations, says she has noticed that some companies marketing ingredients that impact glucose control and weight management are finally having a moment in the Ozempic era, as consumers reading about GLP-1 drugs start looking for natural alternatives
Some patients experience what they describe as a plateau
