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In mouse, a NOD.H-2h4 strain prone to AIT and susceptible individuals, excess I increases the number of intrathyroidal infiltrating Th17 and inhibits the development of Treg, causes abnormal expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in thyrocytes, leading to their apoptosis (44, 45)

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In the context of oral L-glutathione supplements, a true toxic overdose is highly uncommon for most healthy adults

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