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These medications reduce your appetite to promote weight loss

5 Transient cAMP responses to semaglutide in AP Glp1r neurons are -arrestin independent

Neither is licensed for weight loss

One clinical trial found that men with low testosterone and type 2 diabetes who took semaglutide increased their total testosterone by an average of 1.6 nanomoles per liter (nmol/L)

Many patients do not think this risk was properly disclosed to them by Novo Nordisk in a clear and timely manner

Weight loss triggers compensatory mechanisms that increase hunger hormones like ghrelin and decrease satiety signals, creating a biological drive to regain lost weight