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doi: 10.1136/jitc-2025-013269 Summary Keywords digestive tract cancer, ferroptosis, GPX4, immunotherapy, radiotherapy sensitization, SLC7A11, therapeutic Citation Guo J, Wang Z, Zhang Y, Xie C, Chen Y, Ma L, Guo Z and Zhang C (2026) The dual roles of ferroptosis in digestive tract tumors: mechanisms, microenvironment regulation, and therapeutic integration with emphasis on immune interactions

However, lipoxygenase primarily contributes to cysteine starvation-induced ferroptosis rather than GPX4 deficiency-induced ferroptosis

Some glutathione is released directly by the liver into the bloodstream where it helps to maintain the strength of red blood cells and also protects white blood cells

Pregnancy planning : Tirzepatide for weight management should be discontinued if pregnancy occurs or is planned

However, further research is needed to evaluate the interaction mechanism between ketones and NLRP3 and determine its efficacy and safety as a treatment option for acne vulgaris (182)

doi: 10.1007/s11033-025-10261-4 76 ZhaoCWuSWangH