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87 Besides, non-membranolytic actions of AMPs include the destruction of the cytoskeleton in cancer cells, inhibition of DNA and protein synthesis, inhibition of tumor angiogenesis, regulation of immunity, and induction of tumor cell apoptosis or necrosis

This knowledge coupled with the demonstration that some members of the 6-AH family bound with high affi nity to the hinge region of HGF led to the expectation that other active AnglV analogs, like 6-AH family members, could be expected to inhibit HGF dimerization and that the ability of an individual analog to bind HGF and inhibit HGF-dependent processes should be reflected in its capacity to attenuate dimerization

Another model of hyperalgesia is the mu opioid receptor agonist-induced hyperalgesia via stimulation cAMP by PLC and the phosphoinositide signaling cascade which specifically increases prkcg activity (Park et al., 1993)

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(PubMed) Ashor AW, Werner AD, Lara J, Willis ND, Mathers JC, Siervo M