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the physician determines whether the combined approach is appropriate and how to structure each component Convenience preference: patients who strongly prefer not to self-inject and whose indication is compatible with oral delivery

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Oral pigmentation in Addisons disease may be a precursor to more generalised skin hyperpigmentation

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Contraindications : Individuals allergic to cobalt or any other ingredient in the injection should avoid B12 injections

Researchers first began exploring the intravenous administration of glutathione in the 1990s, and no indications of potentially adverse outcomes were observed