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In the recent trial, participants on the highest 36-milligram dose had about a 2 percent greater risk of a serious adverse event, compared with those given a placebo

*Correspondence: Mateusz Maciejczyk, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Oral vs Intravenous Indeed, after several searches in scientific literature, only a single case report was found describing a possible link between oral methylene blue and serotonin syndrome 27

Although glucose is not the primary energy substrate in the normal heart, its metabolism plays an essential role in maintaining cellular homeostasis and supporting rapid responses to metabolic stress (57)