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Clinical studies provide direct evidence: GLP-1 analogue therapy significantly reduced sCD163 (a marker of inflammatory macrophage activation), independent of changes in body weight, fructosamine, and HbA1c

Gradually increase to avoid indigestion and discomfort

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Around 10% is excreted in urine

The following formula illustrates the relationship: Concentration (mg/mL) = Vial content (mg) Volume of bacteriostatic water added (mL) Illustrative examples: 2 mg vial + 1 mL bacteriostatic water = 2 mg/mL 2 mg vial + 2 mL bacteriostatic water = 1 mg/mL 5 mg vial + 2 mL bacteriostatic water = 2.5 mg/mL Note that the concentrations in the examples above differ from one another

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