Importantly, the corresponding cleavage of the scissile bond of the 13-membered 23 (HA08) in the closed conformation of IRAP is less prone to occur since there is not enough space for motion of water molecules to interact with the carboxylate group of Glu465
DHRUV KHULLAR: Thank you for having me.
If you see her when you visit us, make sure to say hello, she loves meeting our members and hearing their success stories
Spina A, De Pasquale V, Cerulo G, Cocchiaro P, Della Morte R, Avallone L, et al
The foundational mechanism work has been complemented by translational-research investigations in disease-model systems and by recent contemporary reviews compiling the broader research framework
PMID: 18612058 View source Pickart L, et al