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In melanocytes, the release of exosomes is activated under stress conditions, and these exosomes carry melanocyte-specific antigens such as tyrosinase (TYR), tyrosinase-related protein 1 (TYRP-1), and tyrosinase-related protein 2 (TYRP-2), which can be taken up by DCs to activate the immune response (43)

By contrast, several mutations that decrease the tone of the GH/IGF-1 axis are associated with extended longevity in mice