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4188-A CROSS TALK BETWEEN SIRT6 AND TGF-BETA SIGNALING MODULATE HUMAN NASH-HCC Xiyan Xiang 1 , Xiaochun Yang 1 , Krishanu Bhowmick 1 , Kazufumi Ohshiro 1 , Anil K Vegesna 1 and Lopa Mishra 1,2 , (1)The Institute for Bioelectronic Medicine, Feinstein Institutes for Medical Research, & Cold Spring Harbor Laboratory, Department of Medicine, Division of Gastroenterology and Hepatology, Northwell Health, Manhasset, New York, USA., (2)Center for Translational Medicine, Department of Surgery, the George Washington University, Washington, DC, USA., Washington, DC Background: NASH driven HCC is rising alarmingly in the US

These micronutrients include magnesium, zinc, iron, manganese, chromium and selenium and it has been suggested that some of the protective effects of these micronutrients may be related to their effects on the activity of the antioxidant enzyme glutathione peroxidase

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Efforts to study NASH relying on mouse models with ad libitum feeding of high-fat chow are confounded by strain-dependent effects