glp 1 ra heart failure GLP-1 and HFpEF. GLP-1 RA improves left ventricular diastolic function The cardiovascular effects of GLP-1

Meanwhile, SGLT2is promote weight loss by inducing osmotic diuresis, which reduces body water and increases urinary calorie excretion [62]

The discovery and development of liraglutide and semaglutide

& Kranzler, H

Evaluation of the cardiac and metabolic effects of semaglutide in heart failure with preserved ejection fraction (CAMEO-SEMA) a phase II, prospective, double-blind randomized trial

Maintenance strategies designed for lasting health beyond the weight loss phase

8 Challenges in clinical application Considering the enumerated benefits of GLP-1RA compared to other glucose-lowering drugs including the reduction in HbA1c and weight reduction benefits alongside decreased risk for hypoglycaemia (122) it is not cost effective if used in combination with another incretin (107)